Abstract：From the dimension of the vertical development in history, the spirit of universal fraternity has left an extraordinary profound thought imprint in human thought history, which has an abundant ideological origin and theoretical basis. While its connotation is constantly endowed new contents with the development of the times. No matter how times has changed, Marxism, especially the human-oriented thought of Marxism is always the theoretical cornerstone of the production and development, and the essential theoretical basis of people’s proper interpretation of the socialist spirit of universal fraternity.

Keyword：the spirit of universal fraternity; Marxism; human-oriented thought;